The film is set four years after the events of Guardians of the Galaxy Vol. 2, where the Avengers have been torn apart following the events of Captain America: Civil War. When Thanos arrives on Earth to collect the Infinity Stones for a gauntlet that will allow him to bend reality to his will, the Avengers must join forces with the Guardians of the Galaxy to stop him before his onslaught of destruction puts an end to the universe.